2017-08-19 17:15:412017-08-02 08:59:02
description
glyceraldehyde 3-phosphate dehydrogenase, NAD-dependent, glycolytic enzyme, forms a transhydrogenation cycle with [[protein|GapB]] for balancing of NADPH
glyceraldehyde 3-phosphate dehydrogenase, NAD-dependent, glycolytic enzyme, forms a transhydrogenation cycle with GapB for balancing of NADPH
The protein
Catalyzed reaction/ biological activity
D-glyceraldehyde 3-phosphate phosphate NAD+ = 3-phospho-D-glyceroyl phosphate NADH (according to Swiss-Prot)
This reaction is part of the glycolysis.
D-glyceraldehyde 3-phosphate phosphate NAD = 3-phospho-D-glyceroyl phosphate NADH (according to Swiss-Prot)
This reaction is part of the glycolysis.
The protein
[SW|Cofactors]
NAD+ (does not accept NADP+) [Pubmed|10799476]
NAD (does not accept NADP ) [Pubmed|10799476]
The protein
Additional information
GAP dehydrogenases from different sources (incl. ''Geobacillus stearothermophilus'') were shown to cleave RNA ([Pubmed|12359717])
Moreover, mutations in ''gapA'' from ''B. subtilis'' can suppress mutations in genes involved in DNA replication ([Pubmed|17505547]).
extensive information on the structure and enzymatic properties of GapA can be found at [http://www.proteopedia.org/wiki/index.php/Glyceraldehyde-3-Phosphate_Dehydrogenase Proteopedia]
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
the protein is stable under both glycolytic and gluconeogenic conditions [pubmed|28760849]
GAP dehydrogenases from different sources (incl. ''Geobacillus stearothermophilus'') were shown to cleave RNA ([Pubmed|12359717])
Moreover, mutations in ''gapA'' from ''B. subtilis'' can suppress mutations in genes involved in DNA replication ([Pubmed|17505547]).
extensive information on the structure and enzymatic properties of GapA can be found at [http://www.proteopedia.org/wiki/index.php/Glyceraldehyde-3-Phosphate_Dehydrogenase Proteopedia]
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
References
Original publications