SubtiBank SubtiBank
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2017-08-19 17:15:412017-08-02 08:59:02

description

glyceraldehyde 3-phosphate dehydrogenase, NAD-dependent, glycolytic enzyme, forms a transhydrogenation cycle with [[protein|GapB]] for balancing of NADPH

glyceraldehyde 3-phosphate dehydrogenase, NAD-dependent, glycolytic enzyme, forms a transhydrogenation cycle with GapB for balancing of NADPH

The protein

Catalyzed reaction/ biological activity

D-glyceraldehyde 3-phosphate phosphate NAD+ = 3-phospho-D-glyceroyl phosphate NADH (according to Swiss-Prot)

This reaction is part of the glycolysis.

D-glyceraldehyde 3-phosphate phosphate NAD = 3-phospho-D-glyceroyl phosphate NADH (according to Swiss-Prot)

This reaction is part of the glycolysis.

The protein

[SW|Cofactors]

NAD+ (does not accept NADP+) [Pubmed|10799476]

NAD (does not accept NADP ) [Pubmed|10799476]

The protein

Additional information

GAP dehydrogenases from different sources (incl. ''Geobacillus stearothermophilus'') were shown to cleave RNA ([Pubmed|12359717])

Moreover, mutations in ''gapA'' from ''B. subtilis'' can suppress mutations in genes involved in DNA replication ([Pubmed|17505547]).

extensive information on the structure and enzymatic properties of GapA can be found at [http://www.proteopedia.org/wiki/index.php/Glyceraldehyde-3-Phosphate_Dehydrogenase Proteopedia]

belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

the protein is stable under both glycolytic and gluconeogenic conditions [pubmed|28760849]

GAP dehydrogenases from different sources (incl. ''Geobacillus stearothermophilus'') were shown to cleave RNA ([Pubmed|12359717])

Moreover, mutations in ''gapA'' from ''B. subtilis'' can suppress mutations in genes involved in DNA replication ([Pubmed|17505547]).

extensive information on the structure and enzymatic properties of GapA can be found at [http://www.proteopedia.org/wiki/index.php/Glyceraldehyde-3-Phosphate_Dehydrogenase Proteopedia]

belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

References

Original publications

22517742, 23420519, 22740702, 23034808, 21815947, 21749987, 12850135, 19193632, 18673455, 20444087, 17726680, 16479537, 12622823, 12359717, 10799476, 17505547, 11489127, 12123463, 17218307, 12634343, 17142398, 17114254, 10559165, 15378759, 27449348, 28760849

22517742, 23420519, 22740702, 23034808, 21815947, 21749987, 12850135, 19193632, 18673455, 20444087, 17726680, 16479537, 12622823, 12359717, 10799476, 17505547, 11489127, 12123463, 17218307, 12634343, 17142398, 17114254, 10559165, 15378759, 27449348